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Investigation of 3 Industry-Wide Applied Storage Conditions for Compound Libraries
Stability Through the Ages: The GSK Experience
COMDECOM: Predicting the Lifetime of Screening Compounds in DMSO Solution
Overcoming Problems of Compound Storage in DMSO: Solvent and Process Alternatives
Studies on Repository Compound Stability in DMSO under Various Conditions
Toward a Class-Independent Quantitative Structure−Activity Relationship Model for Uncouplers of Oxidative Phosphorylation
Fluorescence Spectroscopic Profiling of Compound Libraries
Flaviviral Protease Inhibitors Identified by Fragment-Based Library Docking into a Structure Generated by Molecular Dynamics
Characterization of Chemical Libraries for Luciferase Inhibitory Activity
Fragment-Based Design of Small Molecule X-Linked Inhibitor of Apoptosis Protein Inhibitors
Decoys for Docking
A High-Throughput Screen for Aggregation-Based Inhibition in a Large Compound Library
De Novo Discovery of Serotonin N-Acetyltransferase Inhibitors
Small Molecules Block the Polymerization of Z α1-Antitrypsin and Increase the Clearance of Intracellular Aggregates
Assessing the Scaffold Diversity of Screening Libraries
Structure-Based Pharmacophore Design and Virtual Screening for Novel Angiotensin Converting Enzyme 2 Inhibitors
Identification and Validation of Human DNA Ligase Inhibitors Using Computer-Aided Drug Design
A Concise and Scalable Synthesis of High Enantiopurity (−)-d-erythro-Sphingosine Using Peptidyl Thiol Ester−Boronic Acid Cross-Coupling
A Virtual Screening Approach to Finding Novel and Potent Antagonists at the Melanin-Concentrating Hormone 1 Receptor
Discovery of Novel Human Histamine H4 Receptor Ligands by Large-Scale Structure-Based Virtual Screening
Structural Basis of Inhibitor Specificity of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM-1) Kinase
Development of a Novel Virtual Screening Cascade Protocol to Identify Potential Trypanothione Reductase Inhibitors
A Fast Clustering Algorithm for Analyzing Highly Similar Compounds of Very Large Libraries
High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model
Identification of Non-Nucleoside DNA Synthesis Inhibitors of Vaccinia Virus by High-Throughput Screening
Virtual Screening for SARS-CoV Protease Based on KZ7088 Pharmacophore Points
High-throughput Screening for Small-molecule Activators of Neutrophils: Identification of Novel N-Formyl Peptide Receptor Agonists
Relationships between Molecular Complexity, Biological Activity, and Structural Diversity
Modeling of the Aryl Hydrocarbon Receptor (AhR) Ligand Binding Domain and Its Utility in Virtual Ligand Screening to Predict New AhR Ligands
Validation of BKV large T-antigen ATP-binding site as a target for drug discovery
Discovery of O-GlcNAc Transferase Inhibitors. Department of Microbiology and Molecular Genetics, Harvard Medical School
Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay
Novel Small-Molecule Inhibitors of Anthrax Lethal Factor Identified by High-Throughput Screening
Independent Study: TimTec compound library has "the best diversity"
Stability of Screening Compounds in Wet DMSO
Direct Screening of Natural Products Extracts Using Mass Spectrometry
The Effect of Room-Temperature Storage on the Stability of Compounds in DMSO
The Effect of Freeze/Thaw Cycles on the Stability of Compounds in DMSO
Rediscovering Natural Products
A Comparison of Physiochemical Property Profiles of Development and Marketed Oral Drugs

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Drug Discovery News

  • NYBG scientist says the plant world has “great potential” as a source of new medicines There are probably at least 500 medically useful chemicals awaiting discovery in plant species whose chemical constituents have not yet been evaluated for their potential to cure or treat disease, according to a new analysis by a New York Botanical [...]

  • Sydney: Four new anti-cancer compounds have shown promise in inhibiting the growth of tumours, according to a new approach. Jason Smith, doing his M.Phil. in biomolecular sciences from Macquarie University, combined existing knowledge of an enzyme with computational chemistry approach to identify novel (cancer) inhibitors. The enzyme (indoleamine 2,3-dioxygenase) has generated excitement amongst researchers due [...]

  • THE Federal Government’s recent directive to its hospitals to reduce the cost of cancer screening, though very commendable, is long overdue, considering that late diagnosis of the disease has resulted in the high rate of cancer related deaths in the country. Cancer is one of the leading causes of deaths in the world, especially in [...]

  • Scientists report on the development of a nuclear magnetic resonance (NMR)-based method forscreening the metabolomic response of drug-treated mammalian cells to drug therapy. TheSanford-Burnham Medical Research Institute, and Rady Children’s Hospital investigators, say the highly sensitive, fast, and simple method is carried out in 96-well format, and could have particular utility as a method for high-throughput [...]

  • COLLEGE STATION - A powerful topical preventative for HIV, the virus that causes AIDS, could be a step closer to clinical trials, thanks to a newly discovered molecular compound that research at Texas A&M University and the Scripps Research Institute shows dissolves the virus on contact. The ability of the synthetic compound known as “PD 404,182″ [...]

  • The Chem-TCM is the most comprehensive database of its kind and translates more than 12,000 chemicals from more than 300 Chinese herbs used in traditional Chinese medicine (TCM) into Western terminology. “Future researchers will now be able to better understand the chemical basis of remedies that have been in use for thousands of years,” says [...]

  • Initial data from the first ever trial to evaluate autologous cardiac stem cell (CSC) transplants in humans suggests that the treatment improves left ventricular (LV) systolic function by an average of 12% over one year, and reduces infarct size in patients with severe heart failure due to ischemic heart disease. The trial investigators say the results triple the 4% [...]

  • FDA approved Abbott’s in vitro enzyme strip assay for Chagas disease. The Abbott ESA Chagastest detects antibodies to the causative pathogen Trypanosoma cruzi in serum or plasma samples. It is indicated for use as an additional, more specific test on human samples that have been found to be repeatedly reactive using a licensed screening test. The T. cruzi parasite is transmitted through contact with [...]

  • The 5th Anniversary Central Asian International exhibition «Chemical industry – Chemie Uzbekistan» and the 2nd Uzbek International exhibition of plastics and rubber – «Plastex Uzbekistan 2011» will be held from the 16th till the 18th of November 2011, at the Pavilion 1 of OJSS «Uzexpocentre». “ITE UZBEKISTAN” is the organizer of the exhibitions The exhibitions [...]

  • (CBS) A new vaccine that targets ovarian and breast cancer has shown promise in early studies, giving scientists hope they may be closer to stopping the deadly diseases. PICTURES: 25 breast cancer myths busted Known as PANVAC, the vaccine triggers the immune system to attack tumor cells. “With this vaccine, we can clearly generate immune [...]