 Sigma-Aldrich Sigma-Aldrich is pleased to announce the availability of the MyriaScreen Diversity Collection of drug-like screening compounds. The collection, produced in collaboration with TimTec Inc., is the result of careful evaluation, filtering, and refinement of selections from each of our screening compound collections. The MyriaScreen Diversity Collection is comprised of 10,000 high-purity screening compounds handpicked to maximize chemical diversity while maintaining drug-likeness.  TimTec Superior structural diversity - Distinct drug-like properties MyriaScreen was created by combining medicinal chemistry expertise and decades of experience in compound acquisition from diverse sources. TimTec’s proprietary software was used to filter a pool of over 300,000 TimTec and Sigma-Aldrich compounds on the basis of diversity. Additional filters were set to consider MW (>225 and <600), cLogP, H-acceptor, H-donors, and rotatable bonds. Medicinal chemistry specialists refined the selection with great personal attention to remove compounds that were overly represented or not well suited for medicinal chemistry follow-up. MyriaScreen is rich in chemotypes and a valuable source of screening compounds for lead discovery. Ready-to-use format - High purity - Efficient re-supply MyriaScreen is pre-plated for your convenience, 0.5 mg in 250 µL of DMSO per well. The compounds have an average purity > 95% with nothing below 90%. Should you require more material for follow-up, re-supply or re-synthesis is available. Although MyriaScreen is designed for use as a complete set, there are two alternative options to fit your purchasing needs. Compounds can be purchased as individual plates or cherry-picked and plated on a custom basis. Click here for more information or to request a MyriaScreen Diversity Collection SDFile. MyriaScreen was produced in collaboration with TimTec.
Lipinski rule of five | Number of satisfied rules | Percentage of compounds | | H-bond donors | <= 5 | | H-bond acceptors | <= 10 | | Log P | <= 5 | | Mol. Weight | <= 500 | | 1 | 0.00 % | | 2 | 1.00 % | | 3 | 0.93 % | | 4 | 99.04 % |
MyriaScreen Drug-Like Porperties Statistics Graphs 
MyriaScreen Press Release TimTec and Sigma-Aldrich (NASDAQ:SIAL) are pleased to announce the availability of the MyriaScreen Diversity Collection of drug-like screening compounds produced in collaboration, is the result of careful evaluation, filtering, and refinement of selections from each of our screening compound collections. Sigma-Aldrich Introduces the MyriaScreen Diversity Collection for Drug Discovery Newark, DE, September 23, 2005 –(PR.COM)– TimTec and Sigma-Aldrich (NASDAQ:SIAL) are pleased to announce the availability of the MyriaScreen Diversity Collection of drug-like screening compounds produced in collaboration, is the result of careful evaluation, filtering, and refinement of selections from each of our screening compound collections. The MyriaScreen Diversity Collection is comprised of 10,000 high-purity screening compounds handpicked to maximize chemical diversity while maintaining drug-likeness. The MyriaScreen Diversity Collection was assembled from a pool of over 300,000 screening compounds using a combination of filters, diversity predictors, and manual selection. The resulting 10,000 compounds are drug-like, chemically diverse, and amenable to follow-up chemistry and optimization. The collection is well suited for researchers that are looking for a small, cost-effective, ready-to-screen set of high-quality screening compounds. “MyriaScreen will complement our customers’ existing screening collections and jump-start new collections by quickly adding interesting chemotypes,” said Michael Earley, Product Manager, Drug Discovery, Sigma-Aldrich. “Our collaboration with TimTec, Inc. resulted in a high-quality library that our customers will find useful.” About Sigma-Aldrich Sigma-Aldrich Sigma-Aldrich is a leading Life Science and High Technology company. Our biochemical and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and chemical manufacturing. We have customers in life science companies, university and government institutions, hospitals and in industry. Over one million scientists and technologists use our products. Sigma-Aldrich operates in 34 countries and has 6,000 employees providing excellent service worldwide. We are committed to the success of our Customers, Employees and Shareholders through leadership in Life Science, High Technology and Service. To request information about MyriaScreen, please click here . Forward Inquiries to:
Mrs. Kelley Euchner, 800-521-8956
Mr. Timothy Sommer, 314-286-7768 About TimTec
TimTec TimTec Corporation is a privately held company located in Newark Delaware, USA. It was founded in 1995 and began its work in the areas of acquisition and distribution of synthetic organic and natural compounds, custom synthesis, and laboratory equipment to become a full service partner for drug discovery. TimTec has established a global network of thousands of scientists from research centers around the world. The company has developed strong in-house expertise assembling general and targeted library collections for variety of research purposes. International customers include major pharmaceutical, biotech, agricultural, and educational companies and institutions, which use TimTec products for research and development programs.
For further information please contact:
TimTec LLC
Harmony Business Park A-301
Newark DE 19711
Tel 302 292 8500
Fax 302 292 8520
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http://www.timtec.net
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