Screening Collections

Pre-designed libraries for HTS and focused screens

Diversity collections of different sizes, nature-informed sets, and targeted series. Compounds from these libraries are available for cherry-picking. A01 and A02 are in stock in Orlando; A03 is extended overseas stock.

Featured libraries

Selected publications that name a given collection are listed on that collection’s detail page. These are literature reports, not TimTec efficacy claims.

Botanical source material, mortar and pestle, and glass vials of purified white solid for the NPL-800 natural product library
800 compoundsNatural products

NPL-800

NPL-800 is an 800-compound Natural Product Library of pure, primarily plant-sourced compounds for lead identification. Natural molecules are often multi-active and inherently bioavailable; sold complete, by plate, or as singles.

NPL-800 details
Microplate with purple-to-blue well solutions next to three blue-capped vials for the ApexScreen diversity collection
5,040 compoundsStarter diversity

ApexScreen

ApexScreen is a 5,040-compound diversity slice of TimTec stock, assembled with diversity analysis and optional MW, cLogP, and Lipinski filters. Includes naturals and derivatives; useful as a starter deck or add-on.

ApexScreen details
Stacked 96-well plates filled with blue screening solutions in front of a laboratory world-map panel for ActiGlobe-50K
50,000 compoundsActiProbe series

ActiGlobe-50K

Largest predesigned ActiProbe-series set: 50,000 compounds from a multi-million-compound worldwide pool, filtered on Lipinski parameters plus structural flags for hit and ADMET starting points.

ActiGlobe-50K details
Close view of a 96-well microplate containing liquid samples for the ActiProbe-10K screening library
10,000 compoundsCluster sample

ActiProbe-10K

ActiProbe-10K is a 10,000-compound sampling set derived from ActiProbe-25K / ActiGlobe-50K by Jarvis–Patrick clustering of 2D fragment fingerprints (centroids, singletons, and large-cluster members).

ActiProbe-10K details
A clear plastic 96-well microplate and a white rack holding several open amber glass vials on a white laboratory surface, with blurred laboratory glassware and white chemical structural diagrams against a teal background
10,000 compoundsDiversity

MS-10000

MS-10000 is a 10,000-compound high-purity diversity library of largely Lipinski-compliant, lead-like compounds from TimTec stock. DMSO plating is available.

MS-10000 details
Green leaves, bark, a Petri dish of white crystalline solid, and a flask of clear solution for the NDL-3040 natural derivatives library
3,040 compoundsNature-inspired

NDL-3040

NDL-3040 is a 3,040-compound crossover of natural derivatives, analogs, semi-naturals, and mimics — a structural complement to NPL-800 with no claimed overlap.

NDL-3040 details
Amber vials, flowers, dried citrus, and plant-filled test tubes representing the FL-500 flavonoid derivative library
500 compoundsFlavonoids

FL-500

FL-500 assembles 500 flavonoid derivatives around nine core scaffolds (chalcone, flavanone, flavone, flavonol, and related lattices), a frequently screened natural chemotype with generally low toxicity.

FL-500 details
Four open clear glass vials containing white crystalline chemical fragments, interspersed with ball-and-stick molecular models on a light teal surface against a background of faint skeletal chemical structures
3,200 compoundsFragments

FBL – Fragment-Based Library

FBL-3200 gathers 3,200 structurally diverse, soluble fragments (MW 110–290, cLogP ≤ 2.5) for fragment-based drug discovery. Offered dry or in DMSO.

FBL details
A clear 96-well microplate, three open glass vials of white crystalline solid, and a ball-and-stick cyclic molecular model on a pale teal laboratory surface with faint skeletal ring structures in the background
15,200 compoundsMacrocycles

MAC-15000

MAC-15000 is a collection of about 15,200 peptidomimetic macrocycles with conformationally constrained cores that mimic di- and tripeptide motifs for drug discovery.

MAC-15000 details

ActiTarg Series

Targeted libraries from TimTec stock for lattices associated with published target classes, filtered for favorable MW ranges. Counts follow TimTec’s published ActiTarg catalog figures. Papers that name a specific ActiTarg letter are listed on that letter’s detail page.

Teal-capped glass vials of white solid beside a textured teal disc with clustered spherical forms, against skeletal chemical structures, for the ActiTarg-G GPCR ligand library
2,300 compoundsGPCRs

ActiTarg-G

GPCR ligands from lattices relevant to the seven-transmembrane receptor superfamily. 2,300 compounds selected from more than 7,000 candidates across 15+ series.

ActiTarg-G details
Amber and clear sample vials beside a teal protein ribbon model showing helix and sheet folds, for the ActiTarg-K kinase modulator library
6,600+ compoundsKinases

ActiTarg-K

Kinase modulators from TimTec stock (6,600+ compounds), including the 960-compound K960 diversity subset for smaller screens.

ActiTarg-K details
Five teal-capped vials of white crystalline solid next to a white ribbon-style fragment model on a teal surface, for the ActiTarg-P protease inhibitor library
2,000+ compoundsProteases

ActiTarg-P

Low-MW drug-like compounds with potential protease inhibitory activity; 2,000+ members with a 1,520-compound diversity-selected set and smaller plate subsets.

ActiTarg-P details
Teal rack of open glass vials and two Petri dishes of white crystalline solid against peptide-like skeletal structures, for the ActiTarg-S serine proteinase (serpin) library
900 compoundsSerpins

ActiTarg-S

900 small-molecule analogs related to serine proteinase inhibitors (serpins), for assays that need the serpin mechanism class.

ActiTarg-S details
Cluster of open glass vials containing white crystalline solid in front of a recumbent teal glass vessel and a skeletal chemical overlay, for the ActiTarg-I potassium-channel modulator library
1,460 compoundsIon channels

ActiTarg-I

1,460 low-MW, drug-like potassium-channel / ion-channel modulators from lattices associated with Kv1.5 and IKr activity.

ActiTarg-I details
Amber and clear glass vials beside a glowing translucent sphere with molecular-structure overlays, for the ActiTarg-N nuclear receptor ligand library
1,040 compoundsNuclear receptors

ActiTarg-N

1,040 nuclear receptor ligand analogs assembled from cumulative structural features shared across some 90 known ligands.

ActiTarg-N details
Three open glass vials of white crystalline solid beside a stacked teal disc-and-ribbon molecular model, for the ActiTarg-H HDAC inhibitor library
1,700 compoundsHDAC

ActiTarg-H

1,700 analogs of known approved HDAC therapies across classes. Cherry-pick or custom subsets.

ActiTarg-H details
Clear rack of open glass vials containing white crystalline solid in front of a glowing branched molecular graphic, for the ActiTarg-CNS modulator library
3,600 compoundsCNS

ActiTarg-CNS

Structurally diverse CNS-property compounds focused on serotonin, dopamine, and acetylcholine receptor families. Predesigned set of about 3,600; typically 10 mM DMSO.

ActiTarg-CNS details

Other series available on request

The live catalog also lists template-based heterocyclic groups, privileged-structure sets, ActiCom compounds with annotated activities, Diversity Set 10K, plant extracts, and gossypol derivatives. Ask for current plate maps and SDF files rather than assuming a legacy count is still exact.

Formatting

Typical delivery is dry solid or DMSO solution, in 1-dram (3.75 mL) vials or 96- / 384-well plates, at catalog or custom concentration. Contact TimTec for a free consultation on which collection fits the assay capacity and purpose.

Purity statement used across collections: generally at least 95% by high-field 1H-NMR and/or MS, minimum 90%. Re-supply from U.S. stock is offered for library members that remain in inventory.