ActiProbe series · 50,000 compounds
ActiGlobe-50K
The largest predesigned collection in the ActiProbe series: a 50,000-compound diversity set filtered for drug-like starting points.
ActiGlobe-50K is the largest predesigned collection in the ActiProbe Series: 50,000 compounds assembled from a multi-million-compound worldwide candidate pool. Membership is filtered to Lipinski parameters plus additional structural flags that remove undesirable atoms, functionalities, and fragments, aiming at solid chemical starting points for hit and ADMET work. Custom diversity subsets of any size can be assembled from ActiGlobe using TimTec diversity tools.
Purity is stated as generally at least 95% by high-field 1H-NMR and/or MS, consistent with other TimTec collections.
The ActiProbe 2K, 5K, 10K, 15K, and 25K sets share the same clustering logic at smaller cardinalities; ActiGlobe-50K is the parent pool.
Published screens that used ActiGlobe
These are literature reports, not TimTec efficacy claims:
- Choi, H. W.; Chan, C.; Shterev, I. D.; Lynch, H. E.; Robinette, T. J.; Johnson-Weaver, B. T.; Shi, J.; Sempowski, G. D.; Kim, S. Y.; Dickson, J. K.; Gooden, D. M.; Abraham, S. N.; Staats, H. F. Identification of novel mast cell activators using cell-based high-throughput screening. SLAS Discovery 2019, 24(6), 628–640. doi:10.1177/2472555219834699. Duke University HTS; ActiGlobe-50K® (51,040 compounds) purchased from TimTec (also written Acti-Globe 50K).
- Noor, T.; Schultz, D. C.; Zhai, Y.; Snoke, H. E.; Noh, S.; Seabra, G.; Lee, R. E.; Jeong, K. C.; Li, C.; Siddiqi, A. R. A virtual screening and molecular dynamics approach in search of novel antibiotic chemotypes. PLOS One 2026, 21(3), e0341835. doi:10.1371/journal.pone.0341835. Virtual screen including TimTec ActiGlobe-50K (50,000 compounds).
ActiProbe-series publications remain on the ActiProbe-10K page (that set is clustered from ActiGlobe).