NPL-800 Natural Product Library

TimTec’s Natural Product Library (NPL) contains 800 purified natural compounds. The design goal is broad representation of selected natural material, not exclusive IP. Samples are primarily plant-sourced; the remainder come from bacteria, fungi, and animals. Common natural sources and literature pointers are available for most entries.

Natural molecules are often multi-active and frequently more bioavailable than a typical synthetic singleton. NPL is sold as a complete collection, by plate, or as individual compounds, dry or in DMSO at catalog or custom concentration.

Published screens that used NPL

These are literature reports, not TimTec efficacy claims:

• Shaneyfelt, M. E., et al. Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay. Virology Journal, 2006, 3:68. The NPL subset then numbered 280 compounds; 15 showed antiviral activity without cytotoxicity in that assay.
• Bisson, W. H., et al. Modeling of the Aryl Hydrocarbon Receptor (AhR) ligand-binding domain and its use in virtual ligand screening. J. Med. Chem. 2009, 52(18), 5635–5641. (Customer note on file that NPL was used in a physical and virtual screen.)
• Jadhav, A., et al. Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a thiol-protease screen. J. Med. Chem. 2010, 53(1), 37–51.
• Nielsen, A. L., et al. Identification of catechols as histone-lysine demethylase inhibitors. FEBS Lett. 2012, 586(8), 1190–1194. ST057529 from NPL was reported as an inhibitor of ccKDM4C.

Related collections

NDL-3040 extends the same design idea into derivatives and mimics; TimTec states there is no overlap between NPL and NDL membership. See also FL-500.

Purchasing note: NPL is built mainly from known natural compounds that are also sold by other suppliers. TimTec does not claim IP on library members. Products are for R&D use and should be handled by trained personnel.

Request SDF / quote NDL-3040