Nature-informed · 800 compounds

NPL-800 Natural Product Library

800 pure natural compounds assembled as lead-identification material in a screen-ready format.

Botanical source material, mortar and pestle, and glass vials of purified white solid for the NPL-800 natural product library

TimTec NPL-800 is a Natural Product Library of 800 pure natural compounds. Natural molecules are often multi-active across targets and inherently bioavailable; the value of the set is broad diversity of selected natural chemotypes in a screen-ready format. Compounds are primarily plant-sourced, with remaining samples from bacteria, fungi, and animals. Common natural sources and reference information are available for most samples.

NPL-800 is sold as a complete collection, by plate, or as individual compounds, in solid form or in DMSO (pre-plated or at custom concentration). It is one of TimTec’s nature-inspired collections; NDL elaborates on related chemical space with no claimed compound overlap.

Published screens that used NPL

These are literature reports, not TimTec efficacy claims:

  • Shaneyfelt, M. E.; Burke, A. D.; Graff, J. W.; Jutila, M. A.; Hardy, M. E. Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay. Virol. J. 2006, 3:68. doi:10.1186/1743-422X-3-68. TimTec natural product library; 280 purified plant compounds at the time of the screen.
  • Bisson, W. H.; Koch, D. C.; O’Donnell, E. F.; Khalil, S. M.; Kerkvliet, N. I.; Tanguay, R. L.; Abagyan, R.; Kolluri, S. K. Modeling of the aryl hydrocarbon receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands. J. Med. Chem. 2009, 52(18), 5635–5641. doi:10.1021/jm900199u. Virtual screen of 498 TimTec natural compounds (NPL-class / TimTec naturals; the paper does not name NPL-800).
  • Nielsen, A. L.; et al. Identification of catechols as histone-lysine demethylase inhibitors. FEBS Lett. 2012, 586(8), 1190–1194. doi:10.1016/j.febslet.2012.03.001. ST057529 (caffeic acid) from NPL.
  • Watson, V. G.; Drake, K. M.; Napper, A. D. Development of a high-throughput screening-compatible assay for the discovery of inhibitors of the AF4-AF9 interaction using AlphaScreen technology. Assay Drug Dev. Technol. 2013. doi:10.1089/adt.2012.495. Methods name TimTec NPL (680 natural products at that screen), paired with NDL.
  • Chan, J. D.; Day, T. A.; Marchant, J. S. Coalescing beneficial host and deleterious antiparasitic actions as an antischistosomal strategy. eLife 2018, 7:e35755. doi:10.7554/eLife.35755. Screened TimTec NPL-800 and NDL-3000 alongside an NCI natural-product set.
  • Yang, K.; Yin, J.; Yue, X.; Bieber, K.; Riemekasten, G.; Ludwig, R. J.; Petersen, F.; Yu, X. Luteolin peracetate and gossypolone inhibit immune complex-mediated neutrophil activation in vitro and dermal-epidermal separation in an ex vivo model of epidermolysis bullosa acquisita. Front. Immunol. 2023, 14, 1196116. doi:10.3389/fimmu.2023.1196116. Natural product library obtained from TimTec (NPL-800).
  • Clark-Cotton, M. R.; Chen, S. A.; Gomez, A.; Mulabagal, A. J.; Perry, A.; Malhotra, V.; Onishi, M. Imaging-based screen identifies novel natural compounds that perturb cell and chloroplast division in Chlamydomonas reinhardtii. Mol. Biol. Cell 2025, 36(4), br14. doi:10.1091/mbc.E24-09-0425. TimTec Natural Product Library (720 compounds at the time of the screen) obtained from the Duke Functional Genomics Shared Resource.

Related collections

NDL-3040 extends the same design idea into derivatives and mimics; TimTec states there is no overlap between NPL and NDL membership. See also FL-500.

Request SDF / quote NDL-3040