Nature-informed · 500 compounds
FL-500 Flavonoid Derivatives
500 flavonoid derivatives around nine core scaffolds — a frequently screened natural chemotype with generally low toxicity.
Flavonoids are among the most frequently screened natural chemotypes, with a long record in anti-inflammatory, anticancer, and antioxidant studies and generally low toxicity. The TimTec FL-500 assembles 500 flavonoid derivatives around the nine core scaffolds.
- Chalcone
- Flavanone
- Flavone
- Dihydroflavonol
- Flavonol
- Flavan
- Stilbene
- Isoflavonoid
- Neoflavonoid
Custom formatting and cherry-picking are available. SDF access is by request.
Published screens
These papers used TimTec’s 500-compound flavonoid set (nine cores). Literature reports, not TimTec efficacy claims:
- Manner, S.; Skogman, M.; Goeres, D. M.; Vuorela, P.; Fallarero, A. Systematic exploration of natural and synthetic flavonoids for the inhibition of Staphylococcus aureus biofilms. Int. J. Mol. Sci. 2013, 14(10), 19434–19451. doi:10.3390/ijms141019434. Explicit TimTec collection of 500 synthetic and natural flavonoids (nine cores).
- Narwal, M.; Haikarainen, T.; Fallarero, A.; Vuorela, P. M.; Lehtiö, L. Screening and structural analysis of flavones inhibiting tankyrases. J. Med. Chem. 2013, 56(9), 3507–3517. doi:10.1021/jm3018783. Screened 500 natural and naturally derived flavonoids covering nine flavonoid classes.
- Yan, D.; Tajima, H.; Cline, L. C.; Fong, R. Y.; Ottaviani, J. I.; Shapiro, H.; Blumwald, E. Genetic modification of flavone biosynthesis in rice enhances biofilm formation of soil diazotrophic bacteria and biological nitrogen fixation. Plant Biotechnol. J. 2022, 20(11), 2135–2148. doi:10.1111/pbi.13894. Chemical libraries used include the flavonoid derivatives collection FL-500 (TimTec).