ActiTarg Series · 1,040 compounds
ActiTarg-N Nuclear Receptor Ligands
A library of 1,040 analogs selected from a compound pool with cumulative structural features inherent across some 90 known nuclear receptor ligands.
ActiTarg-N comprises 1,040 analogs from TimTec stock selected for cumulative structural features across some 90 known nuclear receptor ligands. The analog pool started with “defragmented” active molecules. TimTec stock was scanned for molecules with the same fragments, reassembled as new chemical possibilities. Additional computational steps drew in compounds with overall structural similarity to known nuclear receptor ligands. Further filtering was used to keep structural diversity in the final selection. The design is a focused-diversity library relevant to this target class.
Nuclear receptors are intracellular proteins that regulate gene transcription. They are a superfamily of 48 structurally related transcription factors that can be regulated by small molecules.
Target pool listed on the legacy page includes ER and estrogen-related receptor; AR; glucocorticoid receptor; RAR; THR; VDR; FXR; PPAR α/γ; LXR; CCR5; mineralocorticoid receptor; PR; constitutive androstane receptor; and others.
Compounds are available for cherry-picking and/or as the 1,040-compound collection in 96- or 384-well plates and in vials.
Published screens
No peer-reviewed screens naming ActiTarg-N were located.
ActiTarg is one of TimTec’s targeted series. See the ActiTarg Series for the other letter collections.