Diversity · 5,040 compounds
ApexScreen
A starter-scale diversity collection drawn from TimTec stock, including a subset of naturals and natural-product derivatives.
ApexScreen is 5,040 compounds selected to represent the diversity of TimTec stock (historically described as 160,000+ compounds) in a smaller format than 10K+ decks. TimTec assembled it with in-house diversity-analysis software from U.S. and overseas inventory, with optional filters for MW, cLogP, and Lipinski parameters.
Besides diverse synthetic chemotypes, ApexScreen includes a number of pure natural compounds from the Natural Product Library. Formatting (mass or concentration) is customizable. Structural data and pricing are provided on request.
Example literature using ApexScreen material
Independent groups have reported hits from ApexScreen-5040 or related TimTec diversity plates. Examples (not product claims):
- Sheen, C.-W., Alptürk, O., Sluis-Cremer, N. Novel high-throughput screen identifies an HIV-1 reverse transcriptase inhibitor with a unique mechanism of action. Biochem. J. 2014, 462, 425–432. Hit APEX57219.
- Kenwood, B. M., et al. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol. Metabolism, 2013. BAM15 identified from a small-molecule screen; TimTec has offered related information on request.
Ask for the current SDF and plate map before designing a campaign; membership can change as lots are retired or replaced.