Diversity · 5,040 compounds

ApexScreen

A 5,040-compound diversity collection selected to represent TimTec stock in a compact format, including naturals and natural-product derivatives.

Microplate with purple-to-blue well solutions next to three blue-capped vials for the ApexScreen diversity collection

ApexScreen is a 5,040-compound diversity collection selected to represent TimTec stock in a compact format relative to larger general screening decks. It is assembled with TimTec diversity analysis to maximize chemical diversity from U.S. and overseas stock, with optional filters on MW, cLogP, and Lipinski parameters. In addition to diverse stock chemotypes, ApexScreen includes a number of pure natural compounds and natural-product derivatives. It is suitable as a starter library or as a diversity add-on to an existing collection. Multiple sample-size and concentration formats are available.

Structural data and pricing are provided on request.

Published screens that used ApexScreen

These are literature reports, not TimTec efficacy claims:

  • LeVine, H., III. P2-341: A robotic screen of a small-molecule chemical library for inhibitors of Aβ oligomer formation. Alzheimers Dement. 2008, 4(4 Suppl.). doi:10.1016/j.jalz.2008.05.1418. Meeting abstract; names Apexscreen 5040.
  • Kenwood, B. M.; et al. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol. Metab. 2014, 3(2), 114–123. doi:10.1016/j.molmet.2013.11.005. ApexScreen 5040 purchased from TimTec; BAM15 / ST056388.
  • Sheen, C.-W.; Alptürk, O.; Sluis-Cremer, N. Novel high-throughput screen identifies an HIV-1 reverse transcriptase inhibitor with a unique mechanism of action. Biochem. J. 2014, 462, 425–432. doi:10.1042/BJ20140365. ApexScreen purchased from TimTec; hit APEX57219.
  • LeVine, H., III; Lampe, L.; Abdelmoti, L.; Augelli-Szafran, C. E. Dihydroxybenzoic acid isomers differentially dissociate soluble biotinyl-Aβ(1–42) oligomers. Biochemistry 2012, 51(38), 7428–7435. doi:10.1021/bi201288x. Follow-on chemistry from the ApexScreen Aβ-oligomer screen.
  • Byrne, F. L.; et al. Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress. Redox Biol. 2020, 28, 101374. doi:10.1016/j.redox.2019.101374. ApexScreen 5040 small-molecule diversity library purchased from TimTec.

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